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KMID : 0869619960130010042
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Journal of Korean Society of Hospital Pharmacists
1996 Volume.13 No. 1 p.42 ~ p.45
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The Dissolution test and Content Uniformity test of Ranitidine HCI Tablets
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Abstract
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Ranitidine is a histamine H₂-receptor antagonist. The drug competitively inhibits the action of histamine H₂ receptors of parietal cells, reducing gastric acid secretion under daytime and nocturnal basal conditions and also when stimulated by food, insulin, amino acid, histamine, or pentagastrin. Ranitidine is used for the short term treatment of endoscopically or radiographically confirmed active duodenal ulcers and Zollinger-Ellison syndrome etc. Drug effect is depend on bioavailability of preparations and also bioavailability is depend on dissolution rate and content uniformity. This study was attempted to evaluate bioavailability of commercial ranitidine HCI tablets. The dissolution test was conducted in artificial gastric juice and artificial intestinal juice using K.P 1 method with three ranitidine HCI preparations (A, B and C) which were pharmaceutically equivalent. The result as following:1) The dissolution rate in artificial gastric juice was higher in the order three different brands A>B>C 2) The dissolution rate in artificial intestinal juice was higher in the order three different brands A>B>C 3) Content uniformity of three different brands was better in such order as B>A>C 4) There was no relationship between dissolution rate and content uniformity
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